U.S. President Donald Trump on Tuesday called Iran the "most destructive force" in the Middle East, blaming Tehran for instability across the region and warning that the United States will never allow it to obtain a nuclear weapon.

President Donald Trump is holding out Saudi Arabia as a model for a reimagined Middle East. He's using his first major foreign trip of his term to emphasize the promise of economic prosperity over instability in a region that is reeling from multiple wars.

President Trump cherishes big, out-of-the-box deals. As he tours the region, Trump should think beyond Iran’s nuclear issue and work to achieve the denuclearization of the entire Middle East.

DUBAI (Reuters) - Recent U.S. sanctions on Iran are not constructive when it comes to negotiations, Iran's foreign ministry spokesperson Esmaeil Baghaei said on Tuesday, after the two countries held a fourth round of nuclear talks on Sunday in Oman.

DUBAI, United Arab Emirates (AP) — Iran and the United States held a fourth round of negotiations Sunday over Tehran’s rapidly advancing nuclear program, just ahead of a visit by President Donald Trump to the Middle East this week.

Addis Ababa’s willingness to work with regional rivals in the Middle East shows its practical approach to foreign relations.

Tehran called Sunday’s meeting “difficult but useful” as the two sides clash over future of Iran’s uranium enrichment.

Trump administration sanctioned firms operating in Iran’s illicit international oil trade, as President Trump offered Tehran a "much brighter future" should it come to a nuclear deal with the U.S.