The Detroit Lions are coming off a 15-2 season and an NFC North championship. They start out the 2025 campaign with a target, and that target is in the crosshairs right off the bat in the freshly released Lions schedule.

With the NFL schedule officially unveiled, here is Lions OnSI's first game-by-game prediction for the Lions' 2025 season. Week 1 - Sunday, Sept. 7 -- at Packers (4:25 p.m. ET) Prediction: 30-23 win (1-0). Week 2 - Sunday, Sept. 14 -- vs. Bears (1 p.m. ET) Week 3 - Monday, Sept. 22 -- at Ravens (8:15 p.m. ET)